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Few specific genes in humans have been definitively linked with hyperovulation or an increased probability of DZ twinning. Assisted reproductive technologies such as in vitro fertilization IVF are also associated with an increased frequency of DZ twins.

Dizygotic twinning. Hum Reprod Update. Epub Nov PubMed: Machin G.

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Familial monozygotic twinning: a report of seven pedigrees. Am J Hum Genet. Epub Apr Pubmed: A genome wide linkage scan for dizygotic twinning in families of mothers of dizygotic twins.

Hum Reprod. Epub Apr 8.

Shur N. The genetics of twinning: from splitting eggs to breaking paradigms.

Over time, mucus buildup and infections result in permanent lung damage, including the formation of scar tissue fibrosis and cysts in the lungs. Most people with cystic fibrosis also have digestive problems.

Some affected babies have meconium ileus, a blockage of the intestine that occurs shortly after birth. Other digestive problems result from a buildup of thick, sticky mucus in the pancreas.

The pancreas is an organ that produces insulin a hormone that helps control blood sugar levels. It also makes enzymes that help digest food. In people with cystic fibrosis, mucus often damages the pancreas, impairing its ability to produce insulin and digestive enzymes. Problems with digestion can lead to diarrhea, malnutrition, poor growth, and weight loss.

In adolescence or adulthood, a shortage of insulin can cause a form of diabetes known as cystic fibrosis-related diabetes mellitus CFRDM. Cystic fibrosis used to be considered a fatal disease of childhood. With improved treatments and better ways to manage the disease, many people with cystic fibrosis now live well into adulthood. Adults with cystic fibrosis experience health problems affecting the respiratory, digestive, and reproductive systems.

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